Description
Product Characteristics:
Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
Synonyms: Androgen receptor associated protein 54, Androgen receptor-associated protein 54, ARA 54, ARA54, E3 ubiquitin protein ligase RNF14, E3 ubiquitin-protein ligase RNF14, FLJ26004, HFB 30, HFB30, HRIHFB2038, RING finger protein 14, RNF 14, Rnf14, RNF14_HUMAN, TRIAD 2, TRIAD2, Triad2 protein.
Target Information: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]